Cellular and molecular mechanisms of HIV-1 integration targeting
نویسندگان
چکیده
منابع مشابه
O14: Cellular and Molecular Mechanisms of Spinal Cord Trauma
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To achieve productive infection, the reverse transcribed cDNA of human immunodeficiency virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this reaction is the viral integrase. However, studies indicate that the virus is assisted by cellular proteins, or co-factors, to achieve integration into the infected cell. The barrier-to-autointegration factor (BAF)...
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We conducted this study to obtain a comprehensive picture of molecular epidemiology of HIV-1 in three neighboring countries, i.e. Afghanistan, Iran, and Pakistan as a basis for discussing possible hypothesis regarding between-country virus transmission. Our results showed that subtype composition differs between these countries with more variation in Pakistan than Iran and Afghanistan. The CRF3...
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the prevalence of spinal cord injury (sci) is about 2.5 million in the worldwide and more than 130,000 new injuries reported each year. regeneration in the cns versus the pns is very different from the other tissues and many factors can prevent regeneration in pns and specially cns. previous researches demonstrated that regeneration of cns can inhibit by inhibitory molecules and glial scar. the...
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Introduction: Spinal cord injury (SCI) following traumatic events is associated with the limited therapeutic options and sever complications, which can be partly due to inflammatory response. Therefore, this study aims to explore the role of inflammation in spinal cord injury. The findings showed that the pathological conditions of nervous system lead to activation of microglia, astrocyte, neut...
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ژورنال
عنوان ژورنال: Cellular and Molecular Life Sciences
سال: 2018
ISSN: 1420-682X,1420-9071
DOI: 10.1007/s00018-018-2772-5